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KMID : 0974620020200020451
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Bulletin of Dongnam Health University
2002 Volume.20 No. 2 p.451 ~ p.459
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Electron Microscopic Study of the Tibial Epiphyseal Plate and Metaphysis of Rat after Fluoride Administered
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Chang Byung-Soo
Lim Do-Seon
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Abstract
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The purpose of this investigation was to study the initial effects of fluoride on bone resorption in the distal tibial epiphyseal plate and adjacent metaphyseal bone from young male rat given drinking water including 300ppm fluoride using by scanning electron microscopy. The tibia revealed an increase in the portion of mature hypertrophied cells of the epiphyseal plates as compared with normal control. The lacunae of rat which administered of fluoride, varied considerably in shape and size. and were arranged irregular forms. In the metaphysis of tibia, the cancellous bone was reduced and the network of trabeculae was sparsely distributed. The trabeculae were thin and evetually disppeared toward the center of the diaphysis. Mineralized bone treated with fluoride were markedly reduce. The surfaces of tibia were rough and irregular. The result of this study indicate that much dose of fluoride on bone include an inhibition of resorption in the epiphyseal plate and structural alternation of a metaphyseal trabecular bone.
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